Endocrine Abstracts

Introduction: Biotin (vitamin B8) is a coenzyme of carboxylases involved in many metabolic pathways and also used in therapeutics as a dietary supplement (diffuse alopecia)(<30 mg/day), in the treatment of rare congenital enzymatic deficiencies (5–40 mg/day) or more recently in the treatment of progressive multiple sclerosis at higher doses (300 mg/day). At such high doses, interferences with thyroid hormones assays using biotin-streptavidin amplification system were ...